Author

G. Seebohm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:electrophysiology· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Cui· 2 shared N. Ritter· 2 shared A. Deyawe Kongmeneck· 1 shared B. Wuensch· 1 shared E. Wrobel· 1 shared J. A. Schreiber· 1 shared J. Shi· 1 shared K. B. Busch· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

J. Cui

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Author profile →

3 papers

Recent·Most cited

Mdivi-1 affects neuronal activity by inhibition of Complex I and respiratory supercomplex assembly

N. Marx, N. Ritter, P. Disse, G. Seebohm, K. B. Busch

This paper identifies that Mdivi-1 inhibits mitochondrial complex I, disrupts supercomplex assembly, and impairs neuronal activity by affecting ATP production and calcium homeostasis.

bioRxiv · Jan 25, 2024 · PreprintCell Biology

An Activator Locks Kv7.1 Channels Open by Electro-Mechanical Uncoupling and Allosterically Modulates its Pore with similarity to phosphatidylinositol-4,5-bisphosphat

M. Moeller, J. A. Schreiber, M. Zaydman, Z. Beller, S. Becker, N. Ritter, E. Wrobel, N. Strutz-Seebohm, N. Decher, J. Cui, N. Schmidt, M. Duefer, B. Wuensch, G. Seebohm

This study identifies two independent mechanisms by which (R)-L3 activates Kv7.1 channels, involving allosteric modulation of the pore and electro-mechanical uncoupling.

bioRxiv · Feb 11, 2021 · PreprintBiophysics

Two-stage electro-mechanical coupling of a Kv channel in voltage-dependent activation

P. Hou, P. W. Kang, A. Deyawe Kongmeneck, N.-D. Yang, Y. Liu, J. Shi, X. Xu, K. M. White, M. A. Zaydman, M. A. Kasimova, G. Seebohm, L. Zhong, X. Zou, M. Tarek, J. Cui

The paper identifies a two-stage electro-mechanical coupling mechanism in KV7.1 channels, where VSD transitions through intermediate and activated states to trigger pore opening.

bioRxiv · Oct 9, 2019Biophysics