NeurosciencebioRxivPreprint
Mutant huntingtin expression in the hypothalamus promotes ventral striatal neuropathology
Rana Soylu-Kucharz, Natalie Adlesic, Marcus Davidsson…·Åsa Petersén
This study shows that mutant huntingtin in the hypothalamus causes ventral striatal neuropathology, including DARPP-32 neuron loss, and disrupts hypothalamus-ventral striatal circuitry in HD mice.
DOI 10.1101/2023.03.04.530949