Cancer BiologyGutPeer-reviewed
Metabolic Reprogramming by Mutant GNAS Creates an Actionable Dependency in Intraductal Papillary Mucinous Neoplasms of the Pancreas
Yuki Makino, Kimal Rajapakshe, Benson Chellakkan Selvanesan…·Fredrik I. Thege
This study shows that mutant GNAS drives a gastric metaplasia gene signature and glycolytic dependency in IPMNs, offering a therapeutic target.
16 citations