Opposing roles of p38α phosphorylation and arginine methylation in driving TDP-43 proteinopathy.
Mari Aikio, Hana M. Odeh, Heike J. Wobst…·James Shorter
This study identifies opposing roles of p38α phosphorylation and arginine methylation in TDP-43 proteinopathy, showing that phosphorylation promotes aggregation while methylation reduces it.