Cell BiologybioRxivPreprint
Telomeric dysfunction triggers an unstable growth arrest leading to irreparable genomic lesions and entry into cellular senescence
Sabrina Ghadaouia, Marc Alexandre Olivier, Aurélie Martinez…·Francis Rodier
This study shows that telomere uncapping does not directly trigger senescence but leads to genomic instability through telomere fusions and DNA breaks, resulting in irreversible damage.
DOI 10.1101/442533