Author

Nicolas Sammy Lee

University of California, Berkeley

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Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Michelle ReidiD· 1 shared Stephen Graf BrohawniD· 1 shared Trevor A. DocteriD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiophysics

Michelle ReidORCID

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1 paper

Recent·Most cited

BiophysicsStructurePeer-reviewedJun 2, 2026

Structural basis for proton inhibition of the two-pore domain K+ channel TASK-1

Trevor A. Docter, Nicolas Sammy Lee, Michelle Reid, Stephen Graf Brohawn

This study determines the cryo-EM structure of TASK-1 at low pH and shows how protonation of an extracellular histidine leads to channel closure, with mutations affecting proton sensitivity.

2 citations

humancryo-EM

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