Environmentally Induced Sperm RNAs Transmit Cancer Susceptibility to Offspring in a Mouse Model
R. S. da Cruz, O. Dominguez, E. Chen, A. K. Gonsiewski, A. Nasir, M. I. Cruz, X. Zou, S. Galli, K. Makambi, M. McCoy, M. O. Schmidt, L. Jin, I. Peran, S. de Assis
This study shows that DDT exposure in male mice alters sperm RNAs, which transmit cancer susceptibility to female offspring through miRNA-10b, leading to increased tumor aggressiveness.
bioRxiv · Mar 23, 2020 · PreprintCancer Biology