Author

M. McCoy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. K. Gonsiewski· 1 shared A. Nasir· 1 shared A. O. Hudson· 1 shared B. Posner· 1 shared C. Zhang· 1 shared E. Chen· 1 shared E. P. Fokoue· 1 shared E. Toprak· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. K. Gonsiewski

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3 papers

Recent·Most cited

Synergistic and antagonistic drug interactions are prevalent but not conserved across acute myeloid leukemia cell lines

F. N. Kalkan, M. S. Yildiz, N. E. Wood, M. Farid, M. McCoy, C. Zhang, M. Lin, B. Posner, S. S. Chung, E. Toprak

This study investigates drug-drug interactions in AML cell lines, finding widespread but non-conserved synergistic and antagonistic effects across different cell lines.

bioRxiv · Feb 23, 2024Cancer Biology

Environmentally Induced Sperm RNAs Transmit Cancer Susceptibility to Offspring in a Mouse Model

R. S. da Cruz, O. Dominguez, E. Chen, A. K. Gonsiewski, A. Nasir, M. I. Cruz, X. Zou, S. Galli, K. Makambi, M. McCoy, M. O. Schmidt, L. Jin, I. Peran, S. de Assis

This study shows that DDT exposure in male mice alters sperm RNAs, which transmit cancer susceptibility to female offspring through miRNA-10b, leading to increased tumor aggressiveness.

bioRxiv · Mar 23, 2020 · PreprintCancer Biology

Function and evolution of B-Raf loop dynamics relevant to cancer recurrence under drug inhibition

G. A. Babbitt, M. L. Lynch, M. McCoy, E. P. Fokoue, A. O. Hudson

This study uses molecular dynamics simulations and machine learning to analyze how B-Raf loop dynamics change under drug inhibition and genetic mutations, showing that ATP competitive inhibitors reduce hyperactivation risks.

bioRxiv · Jan 13, 2020Biophysics