PhysiologybioRxiv
The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice
O. H. Wearing, C. M. Ivy, N. Guttierrez-Pinto…·G. R. Scott
This study shows that increased hemoglobin-O2 affinity in high-altitude deer mice only benefits aerobic thermogenesis if paired with improved tissue O2 diffusion capacity.
DOI 10.1186/s12915-021-01059-4