A nutritional memory impairs survival, transcriptional and metabolic response to dietary restriction in old mice
O. Hahn, L. F. Drews, A. Nguyen, T. Tatsuta, L. Gkioni, O. Hendrich, Q. Zhang, T. Langer, S. Pletcher, M. J. O. Wakelam, A. Beyer, S. Groenke, L. Partridge
This study shows that late-life dietary restriction in mice has a survival and metabolic memory effect, reducing the benefits of switching from ad libitum to restriction.
bioRxiv · Aug 9, 2019 · PreprintPhysiology