A. Beyer

Efficient Generation of Human Pluripotent Stem Cells from Frozen Cord Tissue via Chemical Reprogramming

This study demonstrates an efficient chemical method to generate iPSCs from frozen umbilical cord tissue, highlighting its safety and potential for regenerative medicine.

Proteomic-based stratification of intermediate-risk prostate cancer patients

The paper identifies an 18-protein signature from proteomic data to stratify intermediate-risk prostate cancer patients into low- and high-risk groups for biochemical recurrence.

Probabilities of HIV-1 bNAb development in healthy and chronically infected individuals

The paper uses sequence analysis to predict the likelihood of HIV-1 broadly neutralizing antibody (bNAb) development in healthy and infected individuals, finding that chronic infection is not required for bNAb generation.

NMD is required for timely cell fate transitions by fine-tuning gene expression and controlling translation

This study shows NMD regulates cell fate transitions by controlling Eif4a2 translation and revealing a hierarchy in Smg5, Smg6, and Smg7 functions.

Cis-regulatory evolution spotlights species differences in the adaptive potential of gene expression plasticity

The paper identifies cis-regulatory variants affecting gene expression plasticity in three Arabidopsis species under dehydration stress, showing lineage-specific selective pressures on regulatory changes.

A nutritional memory impairs survival, transcriptional and metabolic response to dietary restriction in old mice

This study shows that late-life dietary restriction in mice has a survival and metabolic memory effect, reducing the benefits of switching from ad libitum to restriction.

A coevolved EDS1-SAG101-NRG1 module mediates cell death signaling by TIR-domain immune receptors

The paper identifies a coevolved EDS1-SAG101-NRG1 module essential for TIR-domain immune receptor-mediated cell death signaling in plants.