T. Langer

Systematic mapping of MCU-mediated mitochondrial calcium signaling networks

This study maps the MCU-mediated mitochondrial calcium signaling network using proteomics, identifying 89 new interactors and their roles in disease-related pathways.

CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy

This study shows CLUH is essential for maintaining mitochondrial function and translation in motoneuronal axons, preventing peripheral neuropathy in mice.

Feasibility of improving manufacturability based on protein engineering

This study evaluates improving manufacturability by increasing the isoelectric point of a fusion protein to enhance purification efficiency and remove impurities.

De novo serine biosynthesis is protective in mitochondrial disease

This study shows that de novo serine biosynthesis protects against mitochondrial disease by maintaining metabolic homeostasis, redox balance, and lipid homeostasis in skeletal muscle.

Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression

This study shows NME6 supplies mitochondria with ribonucleotides to support mitochondrial gene transcription and DNA maintenance, with implications for cancer and autoimmune diseases.

Metabolic rewiring of mitochondria in senescence revealed by time-resolved analysis of the mitochondrial proteome

This study identifies metabolic rewiring in mitochondria during cellular senescence through time-resolved proteomic analysis in human fibroblasts.

Improving Small Molecule pKa Prediction Using Transfer Learning with Graph Neural Networks

The paper develops a graph neural network model for predicting small molecule pKa values, fine-tuned on experimental data and integrated into an open-source tool for accurate protonation state enumeration.

CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

This study shows CLUH regulates astrin-1 expression to link mitochondrial metabolism with cell cycle progression.

High-throughput phenotypic screen for genetic modifiers in patient-derived OPA1 mutant fibroblasts identifies PGS1 as a functional suppressor of mitochondrial fragmentation

This study identifies PGS1 as a genetic modifier that suppresses mitochondrial fragmentation in OPA1 mutant fibroblasts through lipid metabolism modulation.

Disturbed intramitochondrial phosphatidic acid transport impairs cellular stress signaling

This study shows that impaired phosphatidic acid transport into mitochondria disrupts ER membrane homeostasis and impairs glycolytic growth and stress signaling.

A nutritional memory impairs survival, transcriptional and metabolic response to dietary restriction in old mice

This study shows that late-life dietary restriction in mice has a survival and metabolic memory effect, reducing the benefits of switching from ad libitum to restriction.

Computational identification of novel Kir6 channel inhibitors

This study identifies novel Kir6 channel inhibitors using computational methods, validated by experimental analysis, with potential for treating Cantu syndrome.