L. Partridge

Profound geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy

Brief early adulthood rapamycin treatment in Drosophila and mice extends lifespan and maintains gut function through persistent intestinal autophagy and lysosomal enzyme levels.

Sexual identity of enterocytes regulates rapamycin-mediated intestinal homeostasis and lifespan extension

This study shows that rapamycin extends lifespan in female Drosophila but not males, due to sex-specific autophagy regulation in intestinal enterocytes.

Transposable element landscape in Drosophila populations selected for longevity

This study analyzes TE insertions and expression in long-lived Drosophila populations and finds increased TE abundance but reduced expression, suggesting improved telomere maintenance may contribute to longevity.

Deregulated mito-nuclear communication alters chromatin plasticity and differentiation potential of mesenchymal stem cells upon ageing

This study shows that ageing reduces osteogenic potential of mesenchymal stem cells due to deregulated mito-nuclear communication, which leads to hypo-acetylation and chromatin compaction, and that acetate supplementation can reverse these effects.

Long-term in vivo imaging of Drosophila larvae

This paper describes a method for long-term in vivo imaging of Drosophila larvae using anaesthetisation, enabling high-resolution studies of various larval tissues and processes.

A nutritional memory impairs survival, transcriptional and metabolic response to dietary restriction in old mice

This study shows that late-life dietary restriction in mice has a survival and metabolic memory effect, reducing the benefits of switching from ad libitum to restriction.

Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila

The paper tracks proteomic changes in Drosophila with Aβ42 pathology and identifies proteins associated with AD processes.

Drug repurposing for ageing research using model organisms

This study ranks 743 drug-like compounds for their potential to modulate ageing in C. elegans and Drosophila using genetic, structural, and pharmacological data.