Author

O. Hyrien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2

Frequent Co-Authors

B. Audit· 5 shared A. Goldar· 3 shared J.-M. Arbona· 3 shared A. Buschle· 2 shared A. Schepers· 2 shared H. Blum· 2 shared N. Kirstein· 2 shared S. Krebs· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersCell Biology

B. Audit

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5 papers

Recent·Most cited

Neural network and kinetic modelling of human genome replication reveal replication origin locations and strengths

J.-M. Arbona, H. Kabalane, J. Barbier, A. Goldar, O. Hyrien, B. Audit

The paper uses neural networks and kinetic modeling to infer replication origin locations and strengths from replication timing and direction data, revealing that origin efficiency is determined by both licensing and firing steps.

bioRxiv · Dec 15, 2021Biophysics

Human ORC/MCM density is low in active genes and correlates with replication time but does not solely define replication initiation zones

N. Kirstein, A. Buschle, X. Wu, S. Krebs, H. Blum, W. Hammerschmidt, L. Lacroix, O. Hyrien, B. Audit, A. Schepers

The paper examines ORC/MCM density in relation to replication timing and initiation zones, finding no direct correlation with initiation but a link to replication timing.

bioRxiv · Aug 15, 2020Cell Biology

Organization of DNA replication origin firing in Xenopus egg extracts : the role of intra-S checkpoint

D. Ciardo, O. Haccard, H. Narassimprakash, J.-M. Arbona, O. Hyrien, B. Audit, K. Marheineke, A. Goldar

The paper models DNA replication origin firing in Xenopus egg extracts to show checkpoint regulation influences origin clustering dynamics.

bioRxiv · Jun 22, 2020Cell Biology

Active transcription regulates ORC/MCM distribution whereas replication timing correlates with ORC density in human cells

N. Kirstein, A. Buschle, X. Wu, S. Krebs, H. Blum, W. Hammerschmidt, O. Hyrien, B. Audit, A. Schepers

The paper compares ChIP-seq profiles of ORC and MCM proteins with replication timing to show that active transcription affects ORC/MCM distribution and replication timing correlates with ORC density in human cells.

bioRxiv · Sep 23, 2019 · PreprintCell Biology

Universal temporal rate of DNA replication origin firing: A balance between origin activation and passivation

J.-M. Arbona, A. Goldar, O. Hyrien, A. Arneodo, B. Audit

The paper shows that the universal bell-shaped replication origin firing rate can be explained by diffusion of fork components and competition between firing time and DNA replication time.

bioRxiv · Jan 15, 2018Biophysics