H. Blum

ARID1A Mutations Protect Follicular Lymphoma from FAS-dependent Immune Surveillance by Reducing RUNX3/ETS1-Driven FAS-Expression

This study identifies ARID1A mutations in follicular lymphoma that reduce FAS expression, enabling immune evasion by disrupting RUNX3/ETS1 regulation.

Traitor-virus-guided discovery of novel antiviral factors

This study uses HIV-guided CRISPR to identify antiviral factors by analyzing sgRNA enrichment during viral replication.

Gene Therapy for Cardiomyopathy associated with Duchenne Muscular Dystrophy in a Pig Model

This study shows that AAV1.SERCA2a gene therapy improves heart function and reduces arrhythmia in a pig model of Duchenne muscular dystrophy.

Increased pulmonary monocyte infiltration and attenuated phagocytosis defines perinatal dysfunction of innate immunity in Cystic Fibrosis

The paper identifies increased monocyte infiltration and reduced phagocytosis in CF lungs at birth, suggesting innate immune dysfunction and the need for early treatment.

The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes

The paper identifies thyroglobulin gene (Tg) as a permanently upregulated gene in thyrocytes across vertebrates, providing insights into mechanisms of sustained transcriptional activation.

Selection of the Early Genetic Code by Ultraviolet Light

This study quantifies UV stability of DNA sequences and simulates photodamage to proto-genomes, showing UV compatibility of early life and ranking codon evolutionary models by UV resistance.

Sequence Dependent UV Damage of Complete Pools of Oligonucleotides

The paper quantifies UV damage susceptibility of all 4096 hexamer DNA sequences using high-throughput sequencing, revealing sequence context effects on lesion formation.

SARS-CoV-2 variants of concern are dependent on IFITM2 for efficient replication in human lung cells

The paper was withdrawn due to duplicate submission and is not intended for citation.

SARS-CoV-2 variants of concern remain dependent on IFITM2 for efficient replication in human lung cells

This study shows that SARS-CoV-2 variants of concern (VOCs) require IFITM2 for efficient replication in human lung cells, with IFITM2 depletion reducing viral RNA and infectious virus production by over four orders of magnitude.

The Delta variant of SARS-CoV-2 maintains high sensitivity to interferons in human lung cells

This study examines IFN sensitivity of SARS-CoV-2 variants, finding Delta remains as sensitive as early isolates, while Alpha, Beta, and Gamma show increased resistance.

Human ORC/MCM density is low in active genes and correlates with replication time but does not solely define replication initiation zones

The paper examines ORC/MCM density in relation to replication timing and initiation zones, finding no direct correlation with initiation but a link to replication timing.

Histone deacetylase inhibitors butyrate and bufexamac inhibit de novo HIV-1 infection in CD4 T-cells

This study shows that HDAC inhibitors butyrate and bufexamac inhibit de novo HIV-1 infection in CD4 T-cells without reactivating latent virus.

Active transcription regulates ORC/MCM distribution whereas replication timing correlates with ORC density in human cells

The paper compares ChIP-seq profiles of ORC and MCM proteins with replication timing to show that active transcription affects ORC/MCM distribution and replication timing correlates with ORC density in human cells.

Epstein-Barr virus inactivates the transcriptome and disrupts the chromatin architecture of its host cell in the first phase of lytic reactivation

This study shows that EBV lytic reactivation causes global chromatin remodeling and transcriptome disruption in host cells before viral DNA replication.

Antigen-specific T-cell receptor signatures of cytomegalovirus infection

The paper identifies CMV-specific TCRβ signatures as biomarkers for antiviral T-cell responses by analyzing TCRβ sequences from CMV-infected individuals.