Author

A. Schepers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Buschle· 2 shared B. Audit· 2 shared H. Blum· 2 shared N. Kirstein· 2 shared O. Hyrien· 2 shared S. Krebs· 2 shared W. Hammerschmidt· 2 shared X. Wu· 2 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

A. Buschle

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity

Z. Pogacar, J. L. Johnson, L. Krenning, G. De Conti, C. Lieftink, A. Velds, L. Wardak, F. Jochems, K. Groot, A. Schepers, L. Wang, J.-Y. Song, M. van de Ven, O. van Tellingen, R. H. Medema, , R. Leite de Oliveira

The paper identifies that combining indisulam with palbociclib enhances senescence in cancer cells by inhibiting CDK2 kinase activity.

bioRxiv · Oct 18, 2021Cancer Biology

Human ORC/MCM density is low in active genes and correlates with replication time but does not solely define replication initiation zones

N. Kirstein, A. Buschle, X. Wu, S. Krebs, H. Blum, W. Hammerschmidt, L. Lacroix, O. Hyrien, B. Audit, A. Schepers

The paper examines ORC/MCM density in relation to replication timing and initiation zones, finding no direct correlation with initiation but a link to replication timing.

bioRxiv · Aug 15, 2020Cell Biology

Active transcription regulates ORC/MCM distribution whereas replication timing correlates with ORC density in human cells

N. Kirstein, A. Buschle, X. Wu, S. Krebs, H. Blum, W. Hammerschmidt, O. Hyrien, B. Audit, A. Schepers

The paper compares ChIP-seq profiles of ORC and MCM proteins with replication timing to show that active transcription affects ORC/MCM distribution and replication timing correlates with ORC density in human cells.

bioRxiv · Sep 23, 2019 · PreprintCell Biology

Intricate structure of the interphase chromocenter revealed by the analysis of a factor involved in species formation

N. Kochanova, T. Schauer, G. P. Mathias, A. Lukacs, A. Schmidt, A. Flatley, A. Schepers, A. W. Thomae, A. Imhof

The paper uses microscopy and biotinylation to map HMR and HP1a bound chromatin, revealing an intricate structure of the chromocenter and a role for HMR in separating heterochromatin from centromeric chromatin.

bioRxiv · Oct 14, 2018 · PreprintBiochemistry