Cell BiologybioRxivPreprint
The heme biosynthetic enzyme, 5-aminolevulinic acid synthase (ALAS), and GTPases in control of mitochondrial dynamics and ER contact sites, regulate heme mobilization to the nucleus.
O. Martinez-Guzman, M. M. Willoughby, A. Saini…·A. R. Reddi
The paper develops a live-cell assay to study heme trafficking and identifies ALAS and GTPases as regulators of heme mobilization from mitochondria to the nucleus.
DOI 10.1101/734780