Author

O. Laing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. J. Price· 3 shared D. Stavish· 3 shared I. Barbaric· 3 shared A. J. M. Gillis· 1 shared A. L. Harding· 1 shared A. Lam· 1 shared B. M. James· 1 shared D. Baker· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCell Biology

C. J. Price

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Author profile →

3 papers

Recent·Most cited

Aberrant Wnt activation in recurrent genetically variant human pluripotent stem cells impairs cardiomyocyte differentiation and phenotype

T. Wing, C. J. Price, D. Stavish, O. Laing, J. Riley, A. Lam, S. Oh, Y. Atlasi, I. Barbaric

This study shows that genetic variants in human pluripotent stem cells, specifically gains of chromosome 1q, impair cardiomyocyte differentiation and phenotype through aberrant Wnt activation.

bioRxiv · Dec 12, 2023 · PreprintCell Biology

Cytogenetic resource enables mechanistic resolution of changing trends in human pluripotent stem cell aberrations linked to feeder-free culture

D. Stavish, C. J. Price, G. Gelezauskaite, K. A. Leonhard, S. M. Taapken, E. M. McIntire, O. Laing, B. M. James, J. J. Riley, J. Zerbib, D. Baker, A. L. Harding, L. H. Jestice, T. F. Eleveld, A. J. M. Gillis, , I. Barbaric

The paper analyzes genetic changes in human pluripotent stem cells under different culture conditions and identifies a link between feeder-free culture and increased chromosome 1q gains.

bioRxiv · Sep 21, 2023 · PreprintCell Biology

Nucleosides rescue replication-mediated genome instability of human pluripotent stem cells

J. A. Halliwell, T. J. R. Frith, C. J. Price, O. Laing, O. J. Bower, D. Stavish, P. Gokhale, Z. Hewitt, S. El-Khamisy, I. Barbaric, P. W. Andrews

This study shows that exogenous nucleosides reduce replication stress and genomic instability in human pluripotent stem cells by alleviating DNA damage and mitotic errors.

bioRxiv · Nov 23, 2019Cell Biology