J. McCarthy

A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions.

This study evaluates a triple bNAb combination in infant rhesus macaques, showing durable neutralization and effector functions with high predicted prevention efficacy against HIV strains.

Assessing the impact of autologous neutralizing antibodies on rebound dynamics in postnatally SHIV-infected ART-treated infant Rhesus macaques

This study examines how early ART initiation in HIV-infected infants affects antibody development and latent reservoir dynamics, showing their opposing impacts on post-treatment viral rebound.

Comparative Analysis of Within-Host Dynamics of Acute Infection and Viral Rebound Dynamics in Postnatally SHIV-Infected ART-Treated Infant Rhesus Macaques

This study compares acute infection and viral rebound dynamics in ART-treated infant rhesus macaques using a mathematical model to identify increased infected cell death during rebound.

Mycobacterium ulcerans challenge strain selection for a Buruli ulcer controlled human infection model

This paper identifies M. ulcerans JKD8049 as a suitable human challenge strain for Buruli ulcer research due to its stability, antibiotic susceptibility, and ability to produce mycolactone.

Assessing The Impact Of Autologous Neutralizing Antibodies On Viral Rebound In Postnatally SHIV-Infected ART-Treated Infant Rhesus Macaques

This study investigates how the timing of ART initiation affects viral rebound in infant SHIV-infected Rhesus macaques, finding that latent reservoir size and high-potency neutralizing antibodies influence rebound time.

The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts.

This study shows M5717 delays Plasmodium falciparum parasite clearance by preventing host RBC modification, leading to reduced cytoadherence and splenic clearance.

AGAMOUS mediates timing of guard cell formation during gynoecium development

This study shows AGAMOUS represses stomatal development on gynoecial valves in Arabidopsis to align stomatal maturation with fertilization.

Parameter estimation and identifiability analysis for a bivalent analyte model of monoclonal antibody-antigen binding

This paper develops a method for analyzing bivalent analyte binding kinetics in high-throughput SPR data, improving parameter estimation and identifiability through grid search and profile likelihood analysis.

A survey to assess animal methods bias in scientific publishing

The paper surveys scientists and reviewers to assess biases in favor of animal-based methods in scientific publishing, finding that nonanimal studies are often requested to include animal data.

ZBP1 induces inflammatory signaling via RIPK3 and promotes SARS-CoV-2-induced cytokine expression

This study identifies a ZBP1-RIPK1-RIPK3 pathway that promotes SARS-CoV-2-induced cytokine expression through inflammatory signaling independent of cell death.

Th2-like T-follicular helper cells promote functional antibody production during Plasmodium falciparum infection

The paper identifies Th2-like T-follicular helper cells as key drivers of functional antibody production during Plasmodium falciparum infection, suggesting they are targets for improved malaria vaccines.

Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56

The paper shows that PP2A-B56 regulates MPS1 T-loop autophosphorylation, controlling MPS1 activity and mitotic progression.

Depletion of resident muscle stem cells inhibits muscle fiber hypertrophy induced by lifelong physical activity

This study shows that satellite cell depletion limits muscle fiber hypertrophy in response to lifelong physical activity, with muscle type-specific effects on growth mechanisms.

SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis

This study shows SEMA4C promotes osteosarcoma growth and metastasis, with its inhibition reducing tumor progression and suggesting clinical potential.