L. Tilley

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo

Molecular characterisation of Streptococcus pyogenes (StrepA) non-invasive isolates during the 2022-23 UK upsurge

This study characterizes non-invasive Streptococcus pyogenes isolates from a 2022-23 UK scarlet fever upsurge, revealing strain diversity and genomic features associated with different infection types.

The Plasmodium falciparum artemisinin resistance-associated protein Kelch 13 is required for formation of normal cytostomes

This study shows that the Plasmodium falciparum Kelch 13 protein is essential for normal cytostome formation, which is critical for haemoglobin uptake and artemisinin activation.

Pfcerli2, a duplicated gene in the malaria parasite Plasmodium falciparum essential for invasion of erythrocytes as revealed by phylogenetic and cell biological analysis.

This study identifies PfCERLI2 as an essential protein for merozoite invasion in Plasmodium falciparum through phylogenetic and cell biological analysis.

Antibiotic inhibition of the Plasmodium apicoplast decreases haemoglobin degradation and antagonises dihydroartemisinin action

This study shows that apicoplast-targeting antibiotics reduce free haem availability, antagonizing dihydroartemisinin action in Plasmodium falciparum.

Comparative genomic analysis of skin and soft tissue Streptococcus pyogenes isolates from low- and high-income settings

This study compares the genomes of Streptococcus pyogenes isolates from low- and high-income settings, revealing genetic diversity and differences in resistance genes and prophage content.

Virulence determinant, PTP7, controls vesicle budding from the Maurers clefts, adhesin protein trafficking and host cell remodeling in Plasmodium falciparum

The Plasmodium falciparum protein VCAP1 controls Maurer’s cleft morphology, knob architecture and PfEMP1 trafficking

This study identifies VCAP1 as a key protein controlling Maurer’s cleft structure and PfEMP1 trafficking in Plasmodium falciparum, leading to altered parasite growth and RBC deformability.

The metabolic repair enzyme phospho-glycolate phosphatase regulates central carbon metabolism and fosmidomycin sensitivity in Plasmodium falciparum

This study identifies phospho-glycolate phosphatase (PfPGP) as a regulator of central carbon metabolism in Plasmodium falciparum, showing its role in metabolite homeostasis and drug sensitivity.

Ankyrin-1 gene exhibits allelic heterogeneity in conferring protection against malaria

This study identifies two Ank-1 mutations in mice that confer differing protection against Plasmodium chabaudi infections, demonstrating allelic heterogeneity in ankyrin-1's role in malaria resistance.