O. M. Rueda

This study identifies immune phenotype-driven clustering in HR+/HER2- breast cancer from an Asian cohort, deviating from the luminal A-luminal B classification seen in European populations.

This paper uses TNBC patient-derived xenografts to model drug responses and evolutionary dynamics, revealing a novel mechanism of olaparib response and synergistic effects with salinomycin.

The paper develops a gene expression classifier to predict homologous recombination deficiency in triple-negative breast cancer using RNA-seq and WES data from a Malaysian cohort, achieving high accuracy in validation datasets.

The paper finds a biphasic relationship between PIK3CA genotype and transcriptionally inferred PI3K activity and stemness in breast cancer, with mutant allele dosage affecting these traits differently.

This study analyzes molecular profiles of 560 Asian breast tumors, revealing population-specific differences in subtypes, mutations, and immune scores compared to Caucasian populations.