The indoleamine 2,3 dioxygenase pathway drives intratumoral B cell maintenance.
B. A. Johnson, A. K. Aragaki, D. M. Williams, O. Rogers, J. Mountain, L. Luo, W. Zhang, L. Xian, M. Feng, L. Chia, D. Dordai, N. M. Hahn, S. Desiderio, T. S. Johnson, D. J. McConkey, L. M. S. Resar
This study shows that inhibiting the IDO1 pathway reduces tumor-infiltrating B cells in melanoma models, suggesting potential therapeutic strategies for solid tumors.
bioRxiv · Aug 25, 2021 · PreprintImmunology