M. Feng

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by affecting tumor associated macrophages

This study develops a nanobody-enzyme fusion protein targeting PD-L1 and sialic acid, showing anti-tumor effects by modulating tumor-associated macrophages.

A conserved graft formation process in Picea abies and Arabidopsis thaliana identifies the PAT gene family as central regulators of wound healing

Auxin signaling in the cambium promotes tissue attachment and vascular development during Arabidopsis thaliana graft formation

This study shows auxin signaling in procambial tissues is essential for tissue attachment and vascular development during Arabidopsis thaliana graft formation.

Structural basis of CMKLR1 signaling induced by chemerin9

The paper determines the cryo-EM structure of the CMKLR1-Gi complex with chemerin9, revealing molecular mechanisms of signaling and potential for small molecule agonist development.

PME-mediated pectin modifications promote haustoria initiation and xylem bridge development in the parasitic plant Phtheirospermum japonicum

Development of Highly Selective Epoxyketone-based Plasmodium Proteasome Inhibitors with Negligible Cytotoxicity

This study develops highly selective epoxyketone-based proteasome inhibitors effective against Plasmodium falciparum with low cytotoxicity to human cells.

Pharmacokinetics and Pharmacodynamics of Vancomycin derivative LYSC98 in a Murine Thigh Infection Model against Staphylococcus aureus

This study evaluates the PK/PD of LYSC98 against Staphylococcus aureus in a murine model, identifying Cmax/MIC as the best predictor of efficacy.

RNA2Immune: A Manually Curated Database of Experimentally Supported Data Linking Noncoding RNA Regulation to the Immune System

RNA2Immune is a database linking noncoding RNAs to immune functions, diseases, and vaccines, containing 50,433 experimentally supported associations across 42 species.

A well conserved archaeal B-family polymerase functions as a mismatch and lesion extender

The paper characterizes Sulfolobus islandicus DNA polymerase 2 (Dpo2), showing it extends mismatches and lesions but lacks 3-5 exonuclease activity, suggesting a role in DNA repair.

NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of- Function Mice, and Wild-Type Mice and Rats

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

The indoleamine 2,3 dioxygenase pathway drives intratumoral B cell maintenance.

This study shows that inhibiting the IDO1 pathway reduces tumor-infiltrating B cells in melanoma models, suggesting potential therapeutic strategies for solid tumors.

Development of a mini-replicon-based reverse-genetics system for rice stripe tenuivirus

This paper develops a mini-replicon-based reverse-genetics system for RSV, enabling functional analysis of its genes and host interactions in Nicotiana benthamiana.

Neuromodulation of Behavioral Specialization: Tachykinin Signaling Inhibits Task-Specific Behavioral Responsiveness in Honeybee Workers

This study identifies tachykinin peptides as regulators of task-specific behavioral responsiveness in honeybee workers by manipulating their expression and observing behavioral outcomes.

Chicken peripheral blood lymphocyte response to ALV-J infection assessed by single-cell RNA sequencing

This study uses single-cell RNA sequencing to analyze chicken peripheral blood lymphocytes infected with ALV-J, identifying T cell subsets and their molecular responses to infection.

Cytoplasmic and nuclear Sw-5b NLR act both independently and synergistically to dictate full host defense against tospovirus infection

This study shows that the tomato NLR Sw-5b acts in both cytoplasm and nucleus to provide full resistance against tospovirus by blocking different infection stages.

Identification of silkworm hemocyte subsets and analysis of their response to BmNPV infection based on single-cell RNA sequencing

This study uses single-cell RNA sequencing to identify silkworm hemocyte subsets and analyze their response to BmNPV infection, revealing diverse gene expression changes and immune suppression.

Structures of the Cmr-βComplex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas

This study reveals how target RNA binding regulates Cmr-β complex activities through conformational changes, enabling immune responses against genetic invaders.

A systematic review of scientific research focused on farmers in agricultural adaptation to climate change (2008-2017)

This study reviews scientific research on farmers' roles in agricultural adaptation to climate change from 2008-2017, finding limited global representation and methodological diversity.

Rescue of Tomato spotted wilt tospovirus entirely from cDNA clones, establishment of the first reverse genetics system for a segmented (-)RNA plant virus

This paper establishes the first reverse genetics system for a segmented negative-strand RNA plant virus, enabling molecular genetic analysis of its life cycle and pathogenicity.

A Thermodynamic Limit on the Role of Self-Propulsion in Enhanced Enzyme Diffusion

The paper analyzes enzyme self-propulsion and finds that the required propulsion speed and power exceed known active biomolecules and available chemical power.

Autophagy determines osimertinib resistance through regulation of stem cell-like properties in EGFR-mutant lung cancer

This study shows autophagy promotes osimertinib resistance in EGFR-mutant lung cancer by enhancing stem-cell like properties, and inhibiting autophagy reverses resistance.