Author

O. Sieber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Dhillon· 1 shared D. Mouradov· 1 shared E. F. Lee· 1 shared E. Segelov· 1 shared G. Iatropoulos· 1 shared I. Ng· 1 shared I. Y. Luk· 1 shared J. Desai· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Dhillon

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2 papers

Recent·Most cited

SRP19 and the protein secretion machinery is a targetable vulnerability in cancers with APC loss

X. Xi, L. Liu, N. Tuano, J. Tailhades, D. Mouradov, O. Sieber, M. Cryle, E. Segelov, J. Rosenbluh

The paper identifies SRP19 as a vulnerability in cancers with APC loss, showing that reducing SRP19 inhibits proliferation through ER stress.

bioRxiv · Jan 30, 2024 · PreprintCancer Biology

Dual MAPK and HDAC inhibition rewires the apoptotic rheostat to trigger colorectal cancer cell death

L. J. Jenkins, I. Y. Luk, M. Palmieri, W. D. Fairlie, E. F. Lee, K. L. Schoffer, T. Tan, I. Ng, N. Vukelic, J. W. Tse, R. Nightingale, Z. Alam, G. Iatropoulos, M. Ernst, S. Afshar-Sterle, , J. M. Mariadason

This study shows that combining MEK/ERK and HDAC inhibition synergistically induces apoptosis in colorectal cancer cells and organoids, and can be tailored to specific MAPK genotypes.

bioRxiv · Feb 15, 2021 · PreprintCancer Biology