T. Tan

Immunogenicity of autologous and allogeneic human primary cholangiocyte organoids

The immune response to human primary cholangiocyte organoids is ameliorated by donor-recipient HLA matching.

Bridging the Gap: biofilm-mediated establishment of Bacillus velezensis on Trichoderma guizhouense mycelia

This study investigates bacterial-fungal interactions between Bacillus velezensis and Trichoderma guizhouense, showing biofilm-mediated colonization and gene expression changes that reveal complex dynamics in soil microbiota.

Effect of Electroacupuncture Pretreatment on Cognitive Impairment and Mitophagy in Aging Model Rats and its mechanism

This study investigates how electroacupuncture pretreatment affects cognitive impairment and mitophagy in aging rats, finding it improves cognitive function by enhancing mitophagy and mitochondrial function.

Early cytokine-driven adaptation of survival pathways in lymphoid cells during targeted therapies

This study shows that CLL cells rapidly adapt to venetoclax by upregulating pro-survival proteins and cytokines, suggesting combination therapies targeting these pathways could improve treatment outcomes.

Non-physiologic interaction of MG53 with insulin receptor and lack of evidence for MG53's role in controlling insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues.

This study investigates whether MG53 interacts with the insulin receptor and affects Akt phosphorylation in muscle, heart, and liver tissues, finding low binding affinity and no effect on insulin signaling.

Self-Supervised Learning Improves Accuracy and Data Efficiency for IMU-Based Ground Reaction Force Estimation

This paper uses self-supervised learning to improve accuracy and reduce data requirements for estimating ground reaction forces from IMU data.

CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis

This study identifies CRB3's role in navigating Rab11 vesicles to promote γTuRC assembly during ciliogenesis and its regulation of Hh and Wnt signaling in tumorigenesis.

Microtubule Lattice Spacing Governs Cohesive Envelope Formation of Tau Family Proteins

This study shows that tau family proteins form cohesive envelopes around microtubules, regulated by lattice spacing, which differentially affects motor protein movement and microtubule function.

Monoclonal antibodies targeting surface exposed epitopes of Candida albicans cell wall proteins confer in vivo protection in an infection model

The paper develops monoclonal antibodies targeting Candida albicans cell wall proteins that show improved survival and fungal burden reduction in mouse models of systemic candidiasis.

rRNA Biogenesis Regulates Mouse 2C-like State by 3D Structure Reorganization of Peri-Nucleolar Heterochromatin

This study shows that disrupting rRNA biogenesis in mouse embryonic stem cells induces a 2C-like state through reorganization of peri-nucleolar heterochromatin and activation of the 2C program.

Bacillus velezensis stimulates resident rhizosphere Pseudomonas stutzeri for plant health through metabolic interactions

This study identifies metabolic interactions between Bacillus velezensis and Pseudomonas stutzeri in the cucumber rhizosphere that enhance plant growth and salt stress tolerance.

Phase separation on cell surface: a mechanism of basic fibroblast growth factor signal transduction with heparan sulphate

This study shows that basic fibroblast growth factor (bFGF) undergoes liquid-liquid phase separation on the cell surface with heparan sulphate proteoglycans (HSPG), which is essential for downstream signaling.

MG53 slows neuromuscular junction loss and prolongs survival in ALS

This study shows that MG53 reduces neuromuscular junction loss and extends survival in ALS by protecting diaphragm muscle and NMJ integrity.

Dual MAPK and HDAC inhibition rewires the apoptotic rheostat to trigger colorectal cancer cell death

This study shows that combining MEK/ERK and HDAC inhibition synergistically induces apoptosis in colorectal cancer cells and organoids, and can be tailored to specific MAPK genotypes.

Plasmablast-derived antibody response to acute SARS-CoV-2 infection in humans

This study analyzes plasmablast-derived antibodies in three COVID-19 patients, identifying neutralizing antibodies and cross-reactivity with other betacoronaviruses.

Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists

The paper evaluates how peptide context affects GLP-1R signaling and trafficking, showing differences in agonist-mediated responses based on sequence homology and structural features.

Recombinant human MG53 protein preserves mitochondria integrity in cardiomyocytes during ischemia reperfusion-induced oxidative stress

This study shows that recombinant human MG53 protein protects cardiomyocytes from ischemia-reperfusion-induced oxidative stress by preserving mitochondrial integrity.

Performance of bitumen coating sheet using biomass pyrolysis oil

This study evaluates bio-bitumen made from biomass pyrolysis oil as a substitute for petro-bitumen in coating sheets, showing improved adhesion, temperature stability, mechanical strength, and flexibility.

Microtubules Gate Tau Condensation to Spatially Regulate Microtubule Functions

The paper shows microtubules regulate tau condensation, which spatially controls microtubule severing enzymes and motor movement.