Cell BiologybioRxiv
Checkpoint adaptation in repair-deficient cells drives aneuploidy and resistance to genotoxic agents
O. Vydzhak, K. Bender, J. Klermund…·B. Luke
The paper shows that checkpoint adaptation in repair-deficient cells leads to aneuploidy and resistance to genotoxic agents, which can be targeted with TORC1 inhibition.
DOI 10.1016/j.dnarep.2020.102939