Author

B. Luke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

B. Karim· 2 shared K. Saylor· 2 shared N. Martin· 2 shared P. F. Johnson· 2 shared S. Basu· 2 shared S. Lockett· 2 shared T. Andresson· 2 shared A. Busch· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

B. Karim

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Epitope Mapping of SARS-CoV-2 Spike Protein Reveals Distinguishable Antibody Binding Activity of Vaccinated and Infected Individuals.

N. Felbinger, D. P. Trudil, L. L. Loomis, R. Ascione, G. R. Siragusa, S. Haba, A. Mucci, M. Claycomb, S. Snowberger, B. Luke, S. Tsang, S. C. Francesconi

The paper maps epitopes of SARS-CoV-2 spike protein using peptide microarrays to compare antibody binding activity between vaccinated and infected individuals, finding distinct markers in infected individuals.

bioRxiv · Apr 13, 2022 · PreprintImmunology

CK2 signaling from TOLLIP-dependent perinuclear endosomes is an essential feature of KRAS and NRAS mutant cancers

S. Basu, B. Luke, B. Karim, N. Martin, S. Lockett, S. Das, T. Andresson, K. Saylor, S. Kozlov, L. Bassel, D. Esposito, M. Galloux, P. F. Johnson

This study identifies TOLLIP as a critical adaptor for CK2 signaling from perinuclear endosomes in KRAS and NRAS mutant cancers, showing its role in tumor proliferation and progression.

bioRxiv · Apr 5, 2022 · PreprintCancer Biology

3'UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

J. Salotti, N. Asif, S. Basu, A. Das, M. Yang, B. Karim, K. Saylor, N. Martin, D. A. Scheiblin, S. Misra, B. Luke, T. Andresson, S. Lockett, L. Tessarollo, P. F. Johnson

This study identifies a mechanism where 3'UTR-directed mRNA decay inhibits C/EBPβ activation, suppressing senescence in tumor cells and promoting tumor progression.

bioRxiv · Mar 29, 2022Cancer Biology

Integration in or Near Oncogenes Plays Only a Minor Role in Determining the in Vivo Distribution of HIV Integration Sites Before or During Suppressive Antiretroviral Therapy

J. M. Coffin, M. Bale, D. Wells, S. Guo, B. Luke, J. M. Zerbato, M. D. Sobolewski, T. Sia, W. Shao, X. Wu, F. Maldarelli, M. F. Kearney, J. W. Mellors, S. H. Hughes

The paper compares HIV integration site distributions in vivo and in vitro to assess the role of oncogene integration in viral persistence during ART.

bioRxiv · Nov 25, 2020Microbiology

Checkpoint adaptation in repair-deficient cells drives aneuploidy and resistance to genotoxic agents

O. Vydzhak, K. Bender, J. Klermund, A. Busch, S. Reimann, B. Luke

The paper shows that checkpoint adaptation in repair-deficient cells leads to aneuploidy and resistance to genotoxic agents, which can be targeted with TORC1 inhibition.

bioRxiv · Jul 30, 2019Cell Biology