Differential physiological role of BIN1 isoforms in skeletal muscle development, function and regeneration
I. Prokic, B. S. Cowling, C. Kutchukian, C. Kretz, H. Tasfaout, J. Hergueux, O. Wendling, A. Ferry, A. Toussaint, C. Gavriilidis, V. Nattarayan, C. Koch, J. Lainne, R. Combe, L. Tiret, , J. Laporte
This study investigates the differential roles of BIN1 isoforms in skeletal muscle development, function, and regeneration using knockout mice, finding that ubiquitous BIN1 is essential for development while muscle-specific isoforms are critical for regeneration.
bioRxiv · Dec 11, 2018Pathology