The paper identifies new BIN1 interaction partners and shows how BIN1 mutations disrupt proteome-wide interactions, contributing to centronuclear myopathy.

bioRxiv · Feb 14, 2023Biochemistry

Development and evaluation of a formulation of probiont Phaeobacter inhibens S4 for themanagement of vibriosis in bivalve hatcheries

E. Takyi, J. LaPorte, S. Sohn, R. J. Stevick, E. M. Witkop, L. Gregg, A. Chesler-Poole, J. Small, M. M. White, C. Giray, D. C. Rowley, D. R. Nelson, M. Gomez-Chiarri

The paper develops and tests a probiotic formulation of Phaeobacter inhibens S4 to prevent vibriosis in eastern oyster larvae, showing it increases survival after pathogen challenge.

bioRxiv · Dec 27, 2022 · PreprintMicrobiology

BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation

L. Picas, F. Comunale, C. Andre-Arpin, H. Bousquet, F.-C. Tsai, F. Rico, P. Maiuri, J. Pernier, S. Bodin, A.-S. Nicot, J. Laporte, P. Bassereau, B. Goud, C. Gauthier-Rouviere, S. Miserey

This study shows BIN1 is required for filopodia formation by bundling actin and recruiting dynamin and ezrin, dependent on IRSp53 and membrane curvature.

bioRxiv · Mar 21, 2022Cell Biology

Differential physiological role of BIN1 isoforms in skeletal muscle development, function and regeneration

I. Prokic, B. S. Cowling, C. Kutchukian, C. Kretz, H. Tasfaout, J. Hergueux, O. Wendling, A. Ferry, A. Toussaint, C. Gavriilidis, V. Nattarayan, C. Koch, J. Lainne, R. Combe, L. Tiret, , J. Laporte

This study investigates the differential roles of BIN1 isoforms in skeletal muscle development, function, and regeneration using knockout mice, finding that ubiquitous BIN1 is essential for development while muscle-specific isoforms are critical for regeneration.

bioRxiv · Dec 11, 2018Pathology