Binding of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition
J. Fahoum, M. Billan, J. K. Varga, D. Padawer, M. Elgrably-Weiss, P. Basu, M. Stolovich-Rain, L. Baraz, S. Kumari, E. Oiknine-Dijan, M. Kumar, E. Cohen-Kfir, O. Zelig, G. Mayer, M. N. Isupov, , A. Rouvinski
This study shows that SARS-CoV-2 nucleocapsid protein binds to uninfected cells, triggering antibody-mediated complement activation in COVID-19 patients.
bioRxiv · Mar 17, 2024 · PreprintImmunology