A. Friedman

Uterus and cervix anatomical changes and cervix stiffness evolution throughout pregnancy

This study quantifies uterine and cervical structural and biomechanical changes across pregnancy using ultrasound and aspiration measurements in 47 low-risk pregnancies.

Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces robust neutralizing salivary IgA

This study shows that the BNT162b2 mRNA vaccine induces temporary salivary IgA with strong neutralizing activity against SARS-CoV-2.

Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline

This study examines the impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline, finding progressive telomere erosion and infertility without bone marrow failure.

A landscape of synergistic drug combinations in non-small-cell lung cancer

The paper identifies synergistic drug combinations in non-small-cell lung cancer cell lines, finding that synergy often arises from sensitizing resistant models through dual pathway targeting.

Targeted in situ cross-linking mass spectrometry and integrative modeling reveal the architectures of Nsp1, Nsp2, and Nucleocapsid proteins from SARS-CoV-2

This study uses targeted in situ CLMS and integrative modeling to determine the structures of SARS-CoV-2 Nsp1, Nsp2, and N proteins, revealing key interactions and functional insights.

Real-time sharing of drug screening data on the NCATS OpenData Portal accelerates translational research

This paper describes the NCATS OpenData Portal, a platform for real-time sharing of drug screening data that accelerates translational research by enabling immediate access to large-scale datasets.

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.

A geometric basis for surface habitat complexity and biodiversity

The paper develops a geometric theory to explain biodiversity in surface habitats, showing it explains 98% of variation in coral reefs.

Chemical constituents involved in e-cigarette, or vaping product use-associated lung injury (EVALI)

The paper identifies chemical constituents in counterfeit e-cig cartridges linked to EVALI and compares them to medical-grade and CBD cartridges.

The ER cargo receptor SURF4 facilitates efficient erythropoietin secretion

This study identifies SURF4 as an ER cargo receptor that facilitates EPO secretion and suggests its modulation could treat erythropoiesis disorders.

Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

The paper predicts synthetic rescue mediators of resistance to targeted and immunotherapy using tumor transcriptomics and survival data from 10,000 TCGA patients, validating predictions through experimental screens.