B. Zhou

High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

This study identifies high-motility tumor-associated monocytes (TAMos) that drive macrophage infiltration and cancer cell proliferation via IL-6 and MAPK pathways, suggesting IL-6 as a therapeutic target.

A novel functional gene delivery platform based on a commensal human anellovirus demonstrates transduction in multiple tissue types

This paper develops a gene delivery vector based on a human anellovirus, demonstrating transduction in multiple tissues and durable in vivo function in mice.

Development of alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell derived liver organoids

This study develops a human induced pluripotent stem cell-derived liver organoid model of alcoholic liver disease to evaluate drug treatments and replicate key pathological features.

Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria

This study identifies two ilamycin analogs targeting mycobacterial Clp protease components and discovers mutations conferring resistance to these compounds.

Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding

This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.

Semantical and Geometrical Protein Encoding Toward Enhanced Bioactivity and Thermostability

This paper introduces a pre-training framework that combines sequential and geometric encoders to improve protein variant prediction for enhanced bioactivity and thermostability.

Protein Engineering with Lightweight Graph Denoising Neural Networks

This study introduces a lightweight graph neural network for protein engineering that predicts fitness and guides the design of effective mutants with improved physicochemical properties.

Decoupling of the Onset of Anharmonicity between a Protein and Its Surface Water around 200 K

The paper investigates the onset of anharmonicity in a protein and its surface water around 200 K, finding they are decoupled, with the protein's transition being intrinsic and the water's being a resolution effect.

GRAMD2+ alveolar type I cell plasticity facilitates cell state transitions in organoid culture

The paper identifies GRAMD2+ alveolar type I cells as plastic and capable of transitioning through multiple lung epithelial cell states in organoid culture.

Bacterial Efflux Pump Modulators Prevent Bacterial Growth in Macrophages and Under Broth Conditions that Mimic the Host Environment

This paper identifies and improves efflux pump modulators (EPMs) that inhibit bacterial growth in macrophages and enhance antibiotic potency under host-like conditions.

PfAgo-based dual signal amplification biosensor for rapid and highly sensitive detection of alkaline phosphatase activity

This paper develops a PfAgo-based biosensor for detecting alkaline phosphatase activity with high sensitivity and rapid detection.

Modifications of Two ESCRT-I Subunits with Distinct Ubiquitin Chains Regulate Plant Immunity

The paper shows that XBAT35.2 modulates FLS2 stability by ubiquitinating ESCRT-I subunits VPS37-1 and VPS28-2 with distinct ubiquitin chains, enhancing plant immunity.

A conditional protein diffusion model generates artificial programmable endonuclease sequences with enhanced activity

This paper introduces CPDiffusion, a conditional protein diffusion model that generates artificial endonuclease sequences with enhanced activity without labeled data.

An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity that Reverses Carfentanil-Induced Respiratory Depression

This paper develops a human antibody fragment that reverses carfentanil-induced respiratory depression by targeting multiple opioid analogs.

Mn2+-Induced Structural Flexibility Enhances the Entire Catalytic Cycle and the Cleavage of Mismatches in Prokaryotic Argonaute Proteins

This study shows that Mn2+ enhances pAgo protein flexibility, improving catalytic efficiency and mismatch cleavage through structural changes.

Targeting Fibroblast-Endothelial Interactions in LAM Pathogenesis: 3D Spheroid and Spatial Transcriptomic Insights for Therapeutic Innovation

The paper uses 3D spheroids and spatial transcriptomics to identify LAMFs and LECs as key contributors to LAM, with bFGF and VEGF-A as potential therapeutic targets.

Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development

The paper compares placental transcriptomes and histology between native Tibetans and Han migrants, finding sex-biased expression divergence and adaptive histological changes in male-infant placentas.

Distinct regions of the kinesin-5 C-terminal tail are essential for mitotic spindle midzone localization and sliding force

This study identifies functionally important regions in the C-terminal tail of kinesin-5/Cut7 by analyzing truncation mutants in fission yeast, showing their roles in sliding force and midzone localization.

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

Airway secretory cell-derived p63+ progenitors contribute to alveolar regeneration after sterile lung injury

A unifying principle for global greenness patterns and trends

The paper presents a simple model that explains global greenness patterns and trends using two parameters, matching the accuracy of complex vegetation models.

Excessive apoptosis of naïve T cells resulting hyperactivation as a cause of mammalian aging

This study shows that excessive apoptosis in naïve T cells causes hyperactivation and accelerates aging in mice, suggesting T-cell changes are a cause of aging.

Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces robust neutralizing salivary IgA

This study shows that the BNT162b2 mRNA vaccine induces temporary salivary IgA with strong neutralizing activity against SARS-CoV-2.

Bivalent mRNA vaccine improves antibody-mediated neutralization of many SARS-CoV-2 Omicron lineage variants

This study evaluates the neutralizing antibody response to bivalent mRNA vaccines against multiple Omicron variants, showing enhanced neutralization against BQ.1 and BQ.1.1.

MYSM1 co-activates ERα action via histone and non-histone deubiquitination to confer antiestrogen resistance in breast cancer

This study identifies MYSM1 as an ER co-activator that promotes antiestrogen resistance in breast cancer through histone and non-histone deubiquitination.

STING-dependent cytosolic DNA sensing pathway drives the progression to leukemia in TET2-mutated HSPCs

This study shows that TET2 mutations cause DNA damage, activating the cGAS-STING pathway, which drives clonal hematopoiesis and leukemia, and that STING inhibition can suppress these effects in mouse and patient models.

Breast cancer mutations HER2 V777L and PIK3CA H1047R activate the p21/CDK4/6/Cyclin D1 axis driving tumorigenesis and drug resistance.

This study investigates how HER2 V777L and PIK3CA H1047R mutations drive breast cancer tumorigenesis and drug resistance, showing effective combination therapies.

Cross-neutralization and viral fitness of SARS-CoV-2 Omicron sublineages

This study examines the replication and cross-neutralization of SARS-CoV-2 Omicron sublineages in mice and human airway cultures, finding distinct antigenic profiles and bivalent vaccine support.

Alveolar epithelial type 1 cells serve as a cell of origin for lung adenocarcinoma with distinct molecular and phenotypic presentation

This study identifies alveolar epithelial type 1 cells as a potential cell of origin for lung adenocarcinoma, showing distinct molecular and histological features based on cell of origin.

Endosomal Trafficking of Two Pore K+ Efflux Channel TWIK2 to Plasmalemma Mediates NLRP3 Inflammasome Activation and Inflammatory Injury

This study shows that TWIK2 channels are trafficked from endosomes to the plasma membrane via Rab11a in response to ATP, leading to K+ efflux and NLRP3 inflammasome activation, which can be inhibited to reduce inflammation.