Cancer BiologybioRxiv
The failure of B cells to induce non-canonical MYD88 splice variants correlates with lymphomagenesis via sustained NF-κB signaling
Y. Cardona Gloria, S. H. Bernhart, S. Fillinger…·A. N. Weber
The paper shows that B cells lack a negative feedback loop that normally limits TLR signaling through MYD88 splice variants, leading to sustained NF-κB activation and lymphomagenesis.
DOI 10.3389/fimmu.2021.616451