S. Ossowski

Comparative multi-OMICS single-cell atlas of five COVID-19 (rAdVV and mRNA) vaccines describe unique and distinct mechanisms of action

This study compares the mechanisms of action of five COVID-19 vaccines using multi-omics single-cell data, revealing distinct immune responses and cell-type-specific effects.

Immune dynamics at single cell protein level after delta/omicron infection in COVID-19 vaccinated convalescent individuals

This study examines immune dynamics at the protein level in vaccinated individuals infected with delta or omicron variants, finding reduced NK cells and increased T and B cells, and that booster doses reduce infection severity.

Single-cell RNA sequencing highlights a reduced function of natural killer and cytotoxic T cells in recovered COVID-19 pregnant women

This study uses single-cell RNA sequencing to show that SARS-CoV-2 infection reduces cytotoxic function in natural killer and CD8+ T cells in recovered pregnant women.

Cell-free DNA (cfDNA) and exosome profiling from a year-long humanspaceflight reveals circulating biomarkers

This study profiles cfDNA and exosomes from an astronaut during a year-long spaceflight, identifying increased cf-mtDNA and exosomal brain-derived peptides as potential biomarkers of spaceflight-related stress.

SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells

This study examines how SARS-CoV-2 infection affects CD8+ T cell cytotoxicity and immune cell metabolism in COVID-19 patients.

The failure of B cells to induce non-canonical MYD88 splice variants correlates with lymphomagenesis via sustained NF-κB signaling

The paper shows that B cells lack a negative feedback loop that normally limits TLR signaling through MYD88 splice variants, leading to sustained NF-κB activation and lymphomagenesis.