Author

R. Siebert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Akalin· 1 shared A. Horlova· 1 shared A. Kibler· 1 shared A. M. Berghuis· 1 shared A. Mathioudaki· 1 shared A. N. Weber· 1 shared A. Pfaus· 1 shared A. Reisser· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

A. Akalin

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Author profile →

4 papers

Recent·Most cited

A single-cell multi-omic and spatial atlas of B cell lymphomas reveals differentiation drives intratumor heterogeneity

D. Fitzgerald, T. Roider, M. A. Baertsch, A. Kibler, A. Horlova, E. K. Chung, H. Voehringer, A. Mathioudaki, B. Budeus, V. Passerini, M. Knoll, J. Mammen, L. Li, L. Caille, F. Czernilofsky, , W. Huber

This study reveals that cellular differentiation drives intratumor heterogeneity in B-cell lymphomas, with distinct maturation states associated with different survival outcomes.

bioRxiv · Nov 6, 2023 · PreprintCancer Biology

A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma

N. Schleussner, P. Cauchy, V. Franke, M. Giefing, O. Fornes, N. Vankadari, S. Assi, M. Costanza, M. A. Weniger, A. Akalin, I. Anagnostopoulos, T. Bukur, M. G. Casarotto, F. Damm, O. Daumke, , R. Grosschedl

This study identifies a mutation in IRF4 that alters DNA-binding specificity and gene regulation in lymphoma, leading to disease-specific gene up-regulation.

bioRxiv · Dec 29, 2022 · PreprintCancer Biology

Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer

O. J. Chen, E. Castellsague, M. Moustafa-Kamal, J. Nadaf, B. Rivera, S. Fahiminiya, Y. Wang, I. Gamache, C. Pacifico, L. Jiang, J. Carrot-Zhang, L. Witkowski, A. M. Berghuis, S. Schoenberger, D. Schneider, , J. G. Teodoro

The paper identifies CDC20 missense variants linked to familial cancer, showing they impair SAC binding and promote mitotic slippage.

bioRxiv · Sep 13, 2021Cancer Biology

The failure of B cells to induce non-canonical MYD88 splice variants correlates with lymphomagenesis via sustained NF-κB signaling

Y. Cardona Gloria, S. H. Bernhart, S. Fillinger, O.-O. Wolz, S. Dickhöfer, J. Admard, S. Ossowski, S. Nahnsen, R. Siebert, A. N. Weber

The paper shows that B cells lack a negative feedback loop that normally limits TLR signaling through MYD88 splice variants, leading to sustained NF-κB activation and lymphomagenesis.

bioRxiv · Jun 18, 2020Cancer Biology