Olga Mychko

This study investigates the role of astrocytic Stat3 in prion disease, finding it modulates astrocyte reactivity but has limited impact on disease progression, with context-dependent effects.

This study shows that Galectin-3 promotes microglial uptake of PrPSc, slowing prion disease progression by enhancing phagocytic sequestration of prions.

This study shows that P2Y12 receptor knockout increases microglia-neuron body-to-body interactions and accelerates prion disease progression in mice.

The paper shows that in prion diseases, microglia engulf viable neurons during late preclinical stages, independent of the CD11b pathway, and this occurs across multiple brain regions and sCJD subtypes.

The paper investigates how region-specific homeostatic identities of astrocytes influence their reactive phenotypes across different pathological insults.

This study shows that Alzheimer's disease-associated β-Amyloid does not protect against HSV-1 brain infection in 5XFAD mice.