P. A. de Castro

This study shows that sirtuins in Aspergillus fumigatus are important for virulence and pathogenesis, with AfSirE deletion reducing virulence and altering protein acetylation and gene expression.

The paper identifies conidial surface proteins in Aspergillus fumigatus and shows their role in immune evasion during infection.

This study identifies brilacidin as a compound that enhances the antifungal activity of caspofungin against multiple human pathogenic fungi, including overcoming resistance mechanisms.

This study identifies secondary metabolites produced by Aspergillus fumigatus and Pseudomonas aeruginosa during biofilm formation in normoxia and hypoxia, revealing differences in metabolite secretion between monoculture and co-culture.

The paper investigates whether caspofungin tolerance in Aspergillus fumigatus is a population-level or individual-level trait by testing conidia from clinical isolates.

This study identifies conserved transcription factors and genes involved in gliotoxin protection in Aspergillus species through RNA-sequencing and deletion screening.

This paper investigates how acetate utilization by Aspergillus fumigatus affects virulence traits and pathogenicity, showing its role in secondary metabolite secretion, cell wall composition, and in vivo virulence.

This study uses comparative genomics to identify conserved and species-specific genetic elements related to pathogenicity in Aspergillus fungi, revealing evolutionary patterns linked to human disease.

This paper investigates the role of GprM and GprJ GPCRs in A. fumigatus, showing they regulate cell wall integrity, secondary metabolite production, and virulence.