O-GlcNAc modification of oncogenic transcription factor Sox2 promotes protein stability and regulates self-renewal in pancreatic cancer
N. Sharma, V. K. Gupta, P. Dauer, K. Kesh, R. Hadad, B. Giri, A. Chandra, V. Dudeja, C. Slawson, S. Banerjee, S. M. Vickers, A. Saluja, S. Banerjee
This study shows that O-GlcNAc modification of Sox2 stabilizes the protein and enhances self-renewal in pancreatic cancer, with targeting OGT reducing tumor burden.
bioRxiv · Jun 12, 2018Cancer Biology