Mechanical imbalance between normal and transformed cells drives epithelial homeostasis through cell competition
P. Gupta, S. Kayal, N. Tanimura, S. P. Pothapragada, H. K. Senapati, P. Devendran, Y. Fijita, D. Bi, T. Das
This study identifies a mechanical imbalance between normal and transformed cells in epithelial tissue, showing that transformed cells are more compressible due to weakened adhesions, driving cell competition and homeostasis.
bioRxiv · Sep 27, 2023 · PreprintBiophysics