D. Bi

Regulation of Chromatin Modifications through Coordination ofNucleus Size and Epithelial Cell Morphology Heterogeneity

The paper shows that cell morphology and nucleus size heterogeneity drive chromatin modification changes, affecting euchromatic and heterochromatic marks.

Nuclear size-regulated emergence of topological packing order on growing human lung alveolospheres

This study shows that cell packing order in human lung alveolospheres increases with nucleus-to-cell size ratio, resembling a gas-to-liquid transition, and may regulate organ development and maturation.

Mechanical imbalance between normal and transformed cells drives epithelial homeostasis through cell competition

This study identifies a mechanical imbalance between normal and transformed cells in epithelial tissue, showing that transformed cells are more compressible due to weakened adhesions, driving cell competition and homeostasis.

Matrix confinement modulates 3D spheroid sorting and burst-like collective migration

This study shows that matrix confinement affects 3D spheroid sorting and collective migration, with sorting dependent on cell-cell adhesion and matrix resistance.

Compressive stress drives adhesion-dependent unjamming transitions in breast cancer cell migration

This study identifies compressive stress as a driver of unjamming transitions in breast cancer cell migration by showing that cell-cell adhesion, not epithelial-mesenchymal transition, mediates these changes.

Follicular fluid metabolome and cytokinome profiles in poor ovarian responders and the impact of dehydroepiandrosterone supplementation

This study examines the metabolome and cytokinome of follicular fluid in poor ovarian responders with and without DHEA supplementation, finding significant differences in metabolites and cytokines between groups.

Controlled neighbor exchanges drive glassy behavior, intermittency and cell streaming in epithelial tissues

This study shows that rate-limited T1 transitions in epithelial tissues lead to glassy behavior, intermittency, and cell streaming, with predictions validated against Drosophila pupal development experiments.

The unjamming transition is distinct from the epithelial-to-mesenchymal transition.

This paper distinguishes the unjamming transition (UJT) from the epithelial-to-mesenchymal transition (EMT) by showing UJT enables collective epithelial migration without EMT features.