ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity
A. Fougerat, G. Schoiswohl, A. Polizzi, M. Regnier, C. Wagner, S. Smati, T. Fougeray, Y. Lippi, F. Lasserre, V. Melin, B. Tramunt, C. Alkhoury, A. Emile, M. Schupp, P. Gourdy, , H. Guillou
This study shows that adipose tissue lipolysis via ATGL regulates hepatocyte PPARα activity, which is essential for ketone body production, FGF21 secretion, and BAT activation during fasting and cold exposure.
Cell Reports · Jun 1, 2022Peer-reviewedPhysiology