Author

S. Smati

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. Fougerat· 5 shared A. Polizzi· 5 shared F. Lasserre· 5 shared H. Guillou· 5 shared M. Regnier· 5 shared N. Loiseau· 5 shared S. Ellero-Simatos· 5 shared Y. Lippi· 5 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersPhysiology

A. Fougerat

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

p110alpha-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLD

M. Regnier, A. Polizzi, T. Fougeray, A. Fougerat, P. Perrier, K. Anderson, Y. Lippi, S. Smati, C. Lukowicz, F. Lasserre, E. Fouche, M. Huillet, C. Rives, B. Tramunt, C. Naylies, , H. Guillou

This study investigates the role of p110alpha in hepatocyte signaling, showing its critical impact on liver gene expression and its rewiring in MASLD.

bioRxiv · Jan 9, 2024 · PreprintCell Biology

Obesity promotes Fumonisin B1 toxicity and induces hepatitis

L. Dopavogui, M. Regnier, A. Polizzi, Q. Ponchon, S. Smati, W. Klement, F. Lasserre, C. Lukowicz, Y. Lippi, A. Fougerat, J. Bertrand-Michel, C. Naylies, C. Canlet, L. Debrauwer, L. Gamet-Payrastre, , N. Loiseau

This study shows that obesity increases susceptibility to fumonisin B1 toxicity, leading to gut dysbiosis and severe liver inflammation.

bioRxiv · Jul 22, 2022 · PreprintPharmacology & Toxicology

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

A. Fougerat, G. Schoiswohl, A. Polizzi, M. Regnier, C. Wagner, S. Smati, T. Fougeray, Y. Lippi, F. Lasserre, V. Melin, B. Tramunt, C. Alkhoury, A. Emile, M. Schupp, P. Gourdy, , H. Guillou

This study shows that adipose tissue lipolysis via ATGL regulates hepatocyte PPARα activity, which is essential for ketone body production, FGF21 secretion, and BAT activation during fasting and cold exposure.

Cell Reports · Jun 1, 2022Peer-reviewedPhysiology

The hepatocyte insulin receptor is required to program rhythmic gene expression and the liver clock

T. Fougeray, A. Polizzi, M. Regnier, A. Fougerat, S. Ellero-Simatos, Y. Lippi, S. Smati, F. Lasserre, B. Tramunt, M. Huillet, L. Dopavogui, L. Smith, C. Naylies, C. Sommer, A. Benani, , H. Guillou

This study investigates the role of the hepatocyte insulin receptor in regulating circadian gene expression and liver clock function in adult mice.

bioRxiv · Feb 5, 2021Physiology

Hepatocyte-specific deletion of Pparα promotes NASH in the context of obesity

M. Regnier, A. Polizzi, S. Smati, C. Lukowicz, A. Fougerat, Y. Lippi, E. Fouche, F. Lasserre, C. Naylies, C. Betoulieres, V. Barquissau, E. Mouisel, J. Bertrand-Michel, A. Batut, T. Al Saati, , A. Montagner

This study shows that deleting Ppar in hepatocytes promotes NASH in obese mice without glucose intolerance, highlighting the role of extra-hepatocyte PPAR in metabolic responses to HFD.

bioRxiv · Jan 18, 2019 · PreprintPathology