Y. Lippi

p110alpha-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLD

This study investigates the role of p110alpha in hepatocyte signaling, showing its critical impact on liver gene expression and its rewiring in MASLD.

Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism

This study shows that pharmacological activation of CAR leads to sex-specific changes in hepatic metabolism and drug-induced liver injury in mice.

Obesity promotes Fumonisin B1 toxicity and induces hepatitis

This study shows that obesity increases susceptibility to fumonisin B1 toxicity, leading to gut dysbiosis and severe liver inflammation.

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

This study shows that adipose tissue lipolysis via ATGL regulates hepatocyte PPARα activity, which is essential for ketone body production, FGF21 secretion, and BAT activation during fasting and cold exposure.

The hepatocyte insulin receptor is required to program rhythmic gene expression and the liver clock

This study investigates the role of the hepatocyte insulin receptor in regulating circadian gene expression and liver clock function in adult mice.

Cytolethal Distending Toxin: from mitotic DNA damage to cGAS-dependent pro-inflammatory response

This study identifies mitosis as a critical phase for CDT-induced DNA damage and reveals its role in triggering cGAS-dependent inflammation and cell senescence.

Hepatocyte-specific deletion of Pparα promotes NASH in the context of obesity

This study shows that deleting Ppar in hepatocytes promotes NASH in obese mice without glucose intolerance, highlighting the role of extra-hepatocyte PPAR in metabolic responses to HFD.