C. Postic

p110alpha-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLD

This study investigates the role of p110alpha in hepatocyte signaling, showing its critical impact on liver gene expression and its rewiring in MASLD.

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

This study shows that adipose tissue lipolysis via ATGL regulates hepatocyte PPARα activity, which is essential for ketone body production, FGF21 secretion, and BAT activation during fasting and cold exposure.

Loss of intestinal ChREBP impairs absorption of dietary sugars and prevents glycemic excursion curves

This study shows that loss of intestinal ChREBP reduces glucose absorption and delays glycemic responses by impairing sugar transporters and enzymes.

A Creb3-Like Transcription Factor Coordinates ER Function uponFood Intake to Regulate Lipid Metabolism

This study identifies CrebA as a conserved transcription factor that regulates ER function and lipid metabolism in response to food intake, promoting satiety through a negative feedback loop.

Nuclear HMGB1 protects from non-alcoholic fatty liver diseases through negative regulation of liver X receptor

This study shows that nuclear HMGB1 suppresses liver lipogenesis in NAFLD by inhibiting LXR activity, preventing steatosis and insulin resistance.

The hepatocyte insulin receptor is required to program rhythmic gene expression and the liver clock

This study investigates the role of the hepatocyte insulin receptor in regulating circadian gene expression and liver clock function in adult mice.

Hepatocyte-specific deletion of Pparα promotes NASH in the context of obesity

This study shows that deleting Ppar in hepatocytes promotes NASH in obese mice without glucose intolerance, highlighting the role of extra-hepatocyte PPAR in metabolic responses to HFD.