Liver Fibroblast Growth Factor 21 (FGF21) is Required for the Full Anorectic Effect of the Glucagon-Like Peptide-1 Receptor Agonist Liraglutide in Male Mice fed High Carbohydrate Diets
T. D. V. Le, P. Fathi, A. B. Watters, B. J. Ellis, N. Bozadjieva-Kramer, M. B. Perez, A. I. Sullivan, J. P. Rose, L. L. Baggio, J. Koehler, J. L. Brown, M. B. Bales, K. G. Nwaba, J. E. Campbell, D. J. Drucker, , J. E. Ayala
This study shows that FGF21 is necessary for liraglutide's full weight loss effect in male mice on high-carbohydrate diets, mediated through neuronal pathways.
bioRxiv · Jan 3, 2023 · PreprintPhysiology