A Chemical Toolbox for the Study of Bromodomains and Epigenetic Signaling
Q. Wu, D. Heidenreich, S. Zhou, S. Ackloo, G. Deblois, S. Duan, K. Nakka, J. Dilworth, M. Lupien, P. E. Brennan, C. H. Arrowsmith, S. Mueller, O. Fedorov, P. Filippakopoulos, S. Knapp
The paper presents a set of 25 chemical probes targeting human bromodomains and demonstrates their utility in studying muscle cell differentiation and triple negative breast cancer.
bioRxiv · Aug 14, 2018Cell Biology