Author

M. Lupien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 11 Cell Biology· 2

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Organism:human· 12 Approach:experimental assay· 8 Research Focus:cell type annotation· 7 Approach:statistical model· 7 Research Focus:differential expression· 6 Research Focus:gene regulatory network inference· 6 Research Focus:chromatin & epigenetic regulation· 5 Assay:bulk RNA-seq· 4

Frequent Co-Authors

A. Murison· 7 shared C. Arlidge· 6 shared C. H. Arrowsmith· 3 shared H. Boutzen· 3 shared P. Guilhamon· 3 shared S. Zhou· 3 shared A. Arruda· 2 shared A. Mitchell· 2 shared

Activity by Year

2017-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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7 shared papersCancer Biology

A. Murison

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Author profile →

13 papers

Recent·Most cited

Identification of leukemia stem cell subsets with distinct transcriptional, epigenetic and functional properties

H. Boutzen, A. Murison, J. C. Y. Wang, C. Arlidge, M. Lupien, K. B. Kaufmann, J. E. Dick

The paper identifies two distinct leukemia stem cell subtypes with unique transcriptional, epigenetic, and functional properties using a patient-derived cell model and single-cell analysis.

bioRxiv · Feb 9, 2024Cancer Biology

A primary patient-derived model for investigating functional heterogeneity within the human Leukemic Stem Cell Compartment

H. Boutzen, M. Chan-Seng-Yue, A. Murison, N. Mbong, E. Wagenblast, C. Arlidge, S. A. Madani Tonekaboni, E. Orouji, A. Arruda, A. Mitchell, F. Notta, M. Lupien, M. Minden, K. Kaufmann, J. Dick

bioRxiv · Mar 1, 2022 · PreprintCancer Biology

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

M. M. Szewczyk, G. M. Luciani, V. Vu, A. Murison, D. Dilworth, M. Lupien, C. H. Arrowsmith, M. D. Minden, D. Barsyte-Lovejoy

This study shows PRMT5 regulates ATF4 splicing and oxidative stress response in AML, with EVI1-high cells depending on PRMT5 for redox balance.

bioRxiv · Feb 2, 2022Cancer Biology

Non-coding mutations reveal cancer driver cistromes in luminal breast cancer

S. El Ghamrasni, R. Quevedo, J. R. Hawley, P. Mazrooei, Y. Hanna, I. Cirlan, H. Zhu, J. P. Bruce, L. E. Oldfield, S. Y. C. Yang, P. Guilhamon, J. Reimand, D. Cescon, S. J. Done, M. Lupien, T. Pugh

The paper identifies cancer driver cistromes in luminal breast cancer by analyzing non-coding mutations in cis-regulatory elements from ATAC-seq data and integrating them with somatic mutations.

bioRxiv · May 29, 2021Cancer Biology

Dichotomous regulation of lysosomes by MYC and TFEB controls hematopoietic stem cell fate

L. Garcia-Prat, K. B. Kaufmann, F. Schneiter, V. Voisin, A. Murison, J. Chen, M. Chan-Seng-Yue, O. I. Gan, J. L. McLeod, S. A. Smith, M. C. Shoong, D. Parris, K. Pan, A. G. X. Zeng, G. Krivdova, , J. E. Dick

This study shows that lysosomes are regulated by TFEB and MYC to balance catabolic and anabolic processes in hematopoietic stem cells, influencing their fate and activation.

bioRxiv · Feb 24, 2021 · PreprintCell Biology

Transposable Elements Shape Stemness in Normal and Leukemic Hematopoiesis

G. Grillo, B. Nadorp, A. Qamra, A. Mitchell, C. Arlidge, A. Nand, N. Takayama, A. Murison, S. A. M. Tonekaboni, A. Arruda, J. Wang, M. Minden, O. Deniz, H. Boutzen, J. Dick, M. Lupien

The paper identifies transposable elements (TEs) as genetic drivers of stemness in normal and leukemic hematopoiesis, showing their role in maintaining stem cell properties through chromatin accessibility.

bioRxiv · Feb 16, 2021Cancer Biology

Cis-Regulatory Element Hijacking by Structural Variants Overshadows Higher-Order Topological Changes in Primary Prostate Cancer

J. R. Hawley, S. Zhou, C. Arlidge, G. Grillo, K. Kron, R. Hugh-White, T. van der Kwast, M. Fraser, P. C. Boutros, R. G. Bristow, M. Lupien

The paper shows that structural variants causing cis-regulatory element hijacking have a greater impact on gene expression than changes in three-dimensional chromatin topology in primary prostate cancer.

bioRxiv · Jan 5, 2021Cancer Biology

Single-cell chromatin accessibility in glioblastoma delineates cancer stem cell heterogeneity predictive of survival

P. Guilhamon, M. M. Kushida, A. Nikolic, D. Singhal, G. MacLeod, S. A. M. Tonekaboni, F. M. Cavalli, C. Arlidge, N. Rajakulendran, N. Rastegar, X. Hao, R. Hassam, L. J. Smith, H. Whetstone, F. J. Coutinho, , M. Lupien

The paper uses single-cell chromatin accessibility to identify distinct glioblastoma stem cell states predictive of patient survival.

bioRxiv · Mar 13, 2020 · PreprintCancer Biology

Human papillomavirus integration transforms chromatin to drive oncogenesis

M. Karimzadeh, C. Arlidge, A. Rostami, M. Lupien, S. V. Bratman, M. M. Hoffman

This study shows HPV integration introduces CTCF binding sites, altering chromatin and upregulating essential genes in HPV+ cancers.

bioRxiv · Feb 12, 2020Cancer Biology

GLUT1 inhibition blocks growth of RB1-positive Triple Negative Breast Cancer

Q. Wu, W. Alawi, G. Deblois, J. Cruickshank, S. Duan, E. L. Fernandes, J. Haight, S. A. Tonekaboni, A. Fortier, H. Kuasne, T. McKee, H. Mahmoud, S. Cameron, N. D. Artun, W. Chen, , C. H. Arrowsmith

This study shows that GLUT1 inhibition reduces growth of RB1-positive TNBC cells with high glycolytic activity and low OXPHOS, suggesting a therapeutic target in this subset.

bioRxiv · Sep 11, 2019Cancer Biology

High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma

M. J. Johnston, A. Nikolic, N. Ninkovic, P. Guilhamon, F. M. Cavalli, S. Seaman, F. J. Zemp, J. Lee, A. Abdelkareem, K. Ellestad, A. Murison, M. M. Kushida, F. J. Coutinho, Y. Ma, A. J. Mungall, , M. Gallo

This study uses high-resolution 3D genome maps to identify CD276 as a therapeutic target in glioblastoma stem cells, showing it can suppress self-renewal.

bioRxiv · Oct 13, 2018Cancer Biology

A Chemical Toolbox for the Study of Bromodomains and Epigenetic Signaling

Q. Wu, D. Heidenreich, S. Zhou, S. Ackloo, G. Deblois, S. Duan, K. Nakka, J. Dilworth, M. Lupien, P. E. Brennan, C. H. Arrowsmith, S. Mueller, O. Fedorov, P. Filippakopoulos, S. Knapp

The paper presents a set of 25 chemical probes targeting human bromodomains and demonstrates their utility in studying muscle cell differentiation and triple negative breast cancer.

bioRxiv · Aug 14, 2018Cell Biology

Candidate cancer driver mutations in super-enhancers and long-range chromatin interaction networks

L. Wadi, L. Uuskula-Reimand, K. Isaev, S. Shuai, V. Huang, M. Liang, D. Thompson, Y. Li, L. Ruan, M. Paczkowska, M. Krassowski, I. Dzneladze, K. Kron, A. Murison, P. Mazrooei, , J. Reimand

The paper identifies 41 frequently mutated regulatory elements in cancer genomes, enriched in non-coding mutations and linked to gene expression control through chromatin interactions.

bioRxiv · Dec 19, 2017Cancer Biology