BiochemistrybioRxiv
De-risking drug discovery of intracellular targeting peptides: screening strategies to eliminate false-positive hits
S. Ng, Y.-C. Juang, A. Chandramohan…·D. P. Lane
This paper identifies false-positive peptide inhibitors of KRas using orthogonal assays and cellular screens, highlighting the need for rigorous validation in drug discovery.
DOI 10.1021/acsmedchemlett.0c00022