HIF-stabilization prevents delayed fracture healing
A. Lang, S. Helfmeier, J. Stefanowski, A. Kuppe, V. Sunkara, M. Pfeiffenberger, A. Wolter, A. Damerau, S. Hemmati-Sadeghi, J. Ringe, R. Haag, A. E. Hauser, M. Loehning, C. Perka, G. N. Duda, , F. Buttgereit
This study shows that stabilizing HIF-1α with deferoxamine and macrophage migration inhibitory factor improves fracture healing in a mouse model by enhancing calcification, osteogenic differentiation, and vascularization.
bioRxiv · Jul 2, 2020Bioengineering