BioengineeringbioRxiv
HIF-stabilization prevents delayed fracture healing
A. Lang, S. Helfmeier, J. Stefanowski…·F. Buttgereit
This study shows that stabilizing HIF-1α with deferoxamine and macrophage migration inhibitory factor improves fracture healing in a mouse model by enhancing calcification, osteogenic differentiation, and vascularization.
DOI 10.1016/j.bone.2021.116247